Common use

Letairis (ambrisentan) is prescribed for adults with pulmonary arterial hypertension (PAH) to improve exercise ability and slow disease progression. It works as an endothelin receptor antagonist, blocking the action of endothelin-1, a substance that causes blood vessels in the lungs to narrow.

Dosage and direction

Letairis is usually taken orally once daily, with or without food. Swallow tablets whole with water. Dosage is individualized based on liver function and other health conditions. Regular monitoring of liver function and hemoglobin levels is recommended.

Precautions

Inform your doctor if you have liver disease, heart problems, low blood pressure, or a history of anemia. Avoid pregnancy while taking Letairis, as it may cause birth defects. Monitor for signs of swelling, dizziness, or jaundice.

Contraindications

Do not use Letairis if allergic to ambrisentan or any component of the tablet. It is contraindicated in pregnancy and in patients with severe liver impairment.

Possible side effect

Common side effects include swelling in the legs or ankles, nasal congestion, flushing, headache, and fatigue. Serious side effects may include liver toxicity, low red blood cell counts (anemia), or severe allergic reactions. Seek medical attention if severe symptoms occur.

Drug interaction

Letairis may interact with cyclosporine, rifampin, or other medications that affect liver enzymes. Inform your doctor of all prescription drugs, over-the-counter products, and supplements you are taking.

Missed dose